Frequent Questions Relating to Bioforte

How does Biotivia Achieve a Two Fold Increase in Bioavailability?

Biotivia scientists have extensively researched the pharmacokinetics of resveratrol and have developed the best product in its class. Other companies formulate resveratrol with fillers and excipients or reduce particle size to support a claim of increased bio-availability. These suppliers have no scientific staff or laboratories and often base their formulations upon speculation by non-scientists or data that are not relevant to resveratrol. Biotivia tackles the root problem of the bioavailability of resveratrol through research by our own scientists in our own research facilities and collaboration with respected university pharmacy schools.

How do we achieve enhanced bio-activity? Resveratrol goes through a step called phase I metabolism. Phase I metabolism takes place in your gut and actively attaches enzymes to resveratrol to make it non-active. In the biotech industry companies combat this type of issue in two ways. The first is to use a pro-drug. A pro-drug, which can and often is a natural plant extract, is not active itself but gets degraded into the active drug, in our case resveratrol. In essence this helps resveratrol bypass phase I metabolism and increases the potency and efficacy of our products. Another common practice among biotech companies is to use a pharmacokinetic enhancer. A pharmacokinetic enhancer will allow more resveratrol to enter your body and is an effective means of increasing resveratrol's benefits. The SirT1 activation properties of our resveratrol-based products are to a great extent a function of this enhancement process. The precise method and modifications to standard resveratrol used by Biotivia are trade secrets. However in response to a challenge by one of our competitors our claim of superior bio-availability was upheld by the National Advertising Division of the National BBB after an extensive review of our evidence by their experts. Furthermore, Consumerlab found Transmax and Bioforte to be the two most potent supplements that passed their recent evaluation of resveratrol brands. This is a test that most suppliers chose not to participate in. In our clinical research we have done a one to one human study of Transmax versus pure reference standard resveratrol. We are confident that Biotivia offers truly unique and superior resveratrol-based products in terms of effective potency and bioavailability.

How does Biotivia Insure Product Quality and Prevent Oxidation of its Resveratrol Products?

There is a vast difference in quality amongst various resveratrol products. Biotivia is the only US company that harvests its own raw materials, extracts the resveratrol using a patented low temperature vacuum system with an edible solvent in our own facility and processes the resveratrol with an advanced dry fluid bed granulation system to insure absolutely consistent particle size and quality. We further utilise a bio-enhancement system which we developed to increase bio-availablity of our resveratrol finished products by a factor of at least 2 times that of pharmaceutical grade reference resveratrol. We have over 17 years of experience manufacturing rare botanicals and employ a staff of highly-qualified bio-chemists, botanists, pharmacists and process engineers. Our lab manager has over 35 years of university teaching experience in the fields of food chemistry and nutraceuticals. No company that did not even know resveratrol existed one year ago can match our quality, bio-activity and consistency.

Bioforte contains only bio-enhanced pharmaceutical-grade Resveratrol. Our resveratrol products are made in accordance with FDA, CGMP and US NIH standards. (GMP is the international pharma-standard defined by the U.S. Food & Drug Administration).

Resveratrol is subject to oxidation, which renders the compound totally ineffective. To insure against this Biotivia processes its products in an Oxygen-free environment, fills its bottles with nitrogen gas and uses a patented oxygen-scavenging packaging technology which no other supplement company uses. This Active Packaging sysem captures the free oxygen in the bottle which enters when you take a capsule out of the bottle. With this system your supplement stays fully active for a minimum of 24 months.

Some other companies pack their capsules with inert fillers such as silica, cellulose and rice powder to 'bulk up' the mere 15mg to 100mg of Resveratrol they supply, but Biotivia resveratrol supplements contain only pure Resveratrol. The Pfizer all- vegatable resveratrol capsules themselves are free of titanium dioxide, suitable for vegetarians/vegans, and conform to Jewish, Hindu and Muslim standards.

What is the Difference Between Bioforte and Transmax?

Based on studies done to date, virtually all of the benefits of resveratrol derive from the Trans-resveratrol isomer. Our Bioforte product has 250mg of bio-enhanced "trans-resveratrol" per all-vegetable Pfizer capsule. The remaining 250mg consists of the other forms of resveratrol including glucosides of resveratrol, polydatin, emodin and other beneficial compounds naturally found in the Polygonum Cuspidatum plant. That is why we call Bioforte our full spectrum resveratrol product. Transmax contains 500mg of purified "trans-resveratrol" making it laboratory grade. None of our products contain fillers, inert ingredients, or extraneous chemicals which might interfere with the purity and effectiveness of our formulations. This is an important reason why Transmax and Bioforte are used by scientists, doctors and university researchers when trying to isolate and quantify the effects of trans-resveratrol in various trials and studies. Our buyers include the top research professionals from virtually all of the respected medical schools and research institutions in the US, including Harvard, MIT, Yale, Stanford, Georgetown, University of Pittsburg and many others in Europe and the Asia.

How Many Capsules Should I Take?

Dosage is a very individual choice and depends on your weight, metabolism, individual body chemistry and your primary reasons for taking the product. In general the amount you take should be in proportion to your weight. For example a 90kg (14 stone) man should take roughly twice as much as a  45kg (7 stone) woman, all other things being the same. If you are taking the product for a pre-existing condition then the dosage would be significantly higher than if you were taking resveratrol as part of a preventative regimen. As part of a daily preventative regimen the average adult (i.e. 70kg, 11 stone.) should take 2 Bioforte or 1 Transmax per day. This equates to about £0.70 per day for a supplement which has an extraordinarily wide range of benefits. If, however, you are treating a pre-existing condition many specialists would recommend a much higher dosage, say at least 4 times the preventative dose, or 4 Transmax a day.

When and How Should I Take the Product?

Resveratrol is not very water soluble therefore your body needs to produce enzymes such as bile from the liver and gall bladder to assimilate it. Therefore we recommend that you take our products along with or shortly after taking small amounts of an oily food. This stimulates the production of the necessary enzymes and facilitates absorption. Since our products are natural they can be taken on an empty stomach and will be absorbed more easily if taken at least one hour before or after consuming a substantial meal. Our products may be taken at any time, however early morning is when your body absorbs nutrients most efficiently. To prevent intracellular oxidation of the resveratrol, and this applies to many other polyphenols as well, one should take an anti-oxidant with one's daily resveratrol dose. Although something as simple as one gramme of Vitamin C will help prevent oxidation we naturally recommend that you consider Biotivia's super-fruit extract formulation, Bio Quench, as your choice of anti-oxidant. Bio Quench tested at an ORAC rating per gram of over 13,500. This is the highest rating for any dry compound ever tested by Brunswick Laboratories, the inventor of the ORAC test.

How Should I Store the Products?

Our products are very stable at room temperature but will not be damaged by refrigeration. Either way they will last for at least 2 years on the shelf after opening. Our patented Active Packaging system captures the oxygen which enters the bottle when you retrieve a capsule. No other supplement company uses this technology.