Bio Span+ was designed to complement the life extension properties of Resveratrol by adding concentrated polyphenols and the SirT1 activator silymarin, along with curcumin, and the two critical astragalosides of Astralagus which are believed by many scientists to have telomere protective properties. No other product currently being manufactured compares to Bio Span+ in its potential for enhancement of longevity.
We have devoted quite a bit of study and research to quercetin's effect on resveratrol and Resveratrol's metabolites and the issue of SirT1 activation. Our conclusion is that the most recent and best designed studies, including a study by one company that actually puts Quercetin in their product, conclude that Quercetin strongly inhibits the metabolites of Resveratrol and suppresses SirT1 activation. Quercetin has been shown in numerous studies to interfere with the beneficial metabolites of resveratrol. These metabolites, particularly Resveratrol glucuronide, Resveratrol sulphate and picead possess important health properties. Studies also confirm that enterohepatic recirculation (recirculation by the liver) of these metabolites contributes significantly to the enhanced exposure of Resveratrol in the tissues of mammals. Furthermore, Quercetin's undesirable SirT1 suppression clearly rules it out as an ingredient in any longevity product.
If Biotivia scientists believed that Quercetin would improve our products in a substantive way it would be in our interest to add it to our products. From an economic standpoint this would also benefit us, as Quercetin is far less costly than the high-grade resveratrol we use in our supplements. A recent study by the makers of Longevinex strongly confirms our conclusion that Quercetin inhibits SirT1 and possibly the other sirtuins as well. In this study a combination of Resveratrol and Quercetin, along with the filler oat bran, actually reduced SirT1 activation by a factor of 1.7 times.
Our products are very stable at room temperature but they will not be affected by refrigeration. Either way they will last for at least 2 years on the shelf after opening.
Bio Span dosage is a very individual choice and depends on your weight, metabolism, individual body chemistry and your primary reasons for taking the product. In general the amount you take should be in proportion to your weight. For example a 90kg (14 stone) man should take roughly twice as much as a 45kg (7 stone) woman, all other things being the same. If you are taking the product for a pre-existing condition then the dosage would be significantly higher than if you were taking Resveratrol as part of a preventative regimen. As part of a daily preventative regimen the average adult (i.e. 70kg) should take 2 Bioforte or 1 Transmax per day. This equates to about £0.70 per day for a supplement which has an extraordinarily wide range of benefits. If, however, you are treating a pre-existing condition many specialists would recommend a much higher dosage, say at least 4 times the preventative dose, or 4 Transmax a day.
Resveratrol is not very water soluble therefore your body needs to produce enzymes such as bile from the liver and gall bladder to assimilate it. Therefore we recommend that you take our products along with or shortly after taking small amounts of an oily food. This stimulates the production of the necessary enzymes and facilitates absorption. Since our products are natural they can be taken on an empty stomach and will be absorbed more easily if taken at least one hour before or after consuming a substantial meal. Our products may be taken at any time however early morning is when your body best absorbs nutrients most efficiently. To prevent intracellular oxidation of the Resveratrol, and this applies to many other polyphenols as well, one should take an anti-oxidant with one's daily Resveratrol dose. Although something as simple as one gramme of Vitamin C will help prevent oxidation we naturally recommend that you consider Biotivia's super-fruit extract formulation, Bio Quench, as your choice of anti-oxidant. Bio Quench tested at an ORAC rating per gramme of over 13,500. This is the highest rating for any dry compound ever tested by Brunswick Laboratories, the inventor of the ORAC test.